To make this even easier, I have determined it is best to go with the numbers and trade out Subversion and get Death Rune Mastery. My Heart Strikes and Obliterates won't quite hit as hard on average but overall I will get more Heart Strikes in which should increase my overall threat as well as even it out since I will spam 6 strikes per 10 seconds instead of 4.
Doing the easy math, my OB's hit for 2,249 on Cyanigosa while my Hearts nailed her for 1,750. I'll still use OB's to convert the Unholy and Frost runes over to Death Runes, but that will allow me to pop a lot more Heart Strikes. In addition I am more likely to have a rune available for Blood Boil should an add show up.
Overall single target threat is good as well. We were maybe 15 seconds into the fight and I was already pumping 4,400 TPS in a 5 man with Horn of Winter being my only buff. Give me might, kings, mark of the wild, food, and a flask and this number easily grows past 6,000.
Lastly, I would add that this output was done primarily without the benefit of glyphs. The bone shield and scourge strike glyphs I was rocking just don't add any value to a blood build.
I need to do some research on the new glyphs before I really have some recommendations for blood. Unholy Tanking is easy, the new Pestilence, Scourge Strike, and Bone Shield and you should never have to worry about keeping your diseases up. For blood I would definitely keep the Pestilence, might get the new Plague Strike, and need to think about the third. I am a little torn on the PS one as well. With the pestilence glyph I may not be using PS all that much, even on single target.